کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3954876 | 1600399 | 2009 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Oral misoprostol versus intracervical prostaglandin E2 gel for active management of premature rupture of membranes at term Oral misoprostol versus intracervical prostaglandin E2 gel for active management of premature rupture of membranes at term](/preview/png/3954876.png)
ObjectiveTo compare the efficacy and safety of oral misoprostol with intracervical prostaglandin E2 (PGE2) gel for the active management of premature rupture of membranes (PROM) at term.MethodsWomen with pregnancies between 37 and 42 weeks presenting with PROM at term and a Bishop score of 5 or less were randomly assigned to receive either a 4-hourly oral dose of 50 µg of misoprostol up to a maximum of 3 doses or 2 applications of intracervical PGE2 gel at a 6-hour interval. Oxytocin was given if labor had not started after 12 hours.ResultsTwenty women in the misoprostol group (n = 31) delivered within 12 hours compared with 5 in the PGE2 group (n = 30) (P < 0.001). The induction-to-delivery interval in the misoprostol group was shorter than in the PGE2 gel group (615 min vs 1070 min; P < 0.001). The mode of delivery was comparable between the 2 groups (P = 0.821). Abnormalities in uterine contractions and neonatal outcomes were also comparable. The requirement for oxytocin was lower and patient satisfaction was better in the misoprostol group.ConclusionOral misoprostol is a safe and efficacious alternative to intracervical PGE2 gel in the active management of PROM at term.
Journal: International Journal of Gynecology & Obstetrics - Volume 106, Issue 1, July 2009, Pages 23–26