کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3958527 | 1255419 | 2012 | 6 صفحه PDF | دانلود رایگان |
Study ObjectiveTo estimate the efficacy of alginate carboxymethylcellulose hyaluronic acid (ACH) gel to prevent intrauterine adhesions after hysteroscopic surgery in comparison with carboxymethylcellulose hyaluronic acid (CH) gel, which is known as an effective adhesion inhibitor.DesignRandomized, multicenter, single-blind, clinical trial (Canadian Task Force classification I).SettingTertiary university hospital.PatientsOne hundred eighty-seven patients with a surgically treatable intrauterine lesion (myomas, polyps, septa, intrauterine adhesion, dysfunctional uterine bleeding).InterventionsPatients were randomized to 2 groups: hysteroscopic surgery plus intrauterine application of ACH or CH.Measurements and ResultsThe rate of adhesion formation and the adhesion severity score with type and extent were calculated 4 weeks after surgery. The ACH group had results that were comparable to the CH group in terms of the development of intrauterine adhesions at 4 weeks follow-up. The adhesion severities were not different between the 2 groups. In a subgroup without baseline intrauterine adhesion, the ACH group showed a lower intrauterine adhesion rate than the CH group (p = .016).ConclusionsACH had a comparable efficacy to CH in terms of the adhesion rate and severity. In the case of no baseline intrauterine adhesion, intrauterine application of ACH after hysteroscopic surgery had a lower rate of intrauterine adhesion than application of CH.
Journal: Journal of Minimally Invasive Gynecology - Volume 19, Issue 6, November–December 2012, Pages 731–736