Clinical and Metabolic Features of Polycystic Ovary Syndrome among Chinese Adolescents

ObjectivesTo explore the clinical and metabolic features exhibited by Chinese adolescents with polycystic ovary syndrome (PCOS) and to determine the differences between nonobese and obese adolescent patients with PCOS.DesignClinical cross-sectional study.SettingDepartment of Gynecology and Reproductive Center.Participants25 obese and 66 nonobese adolescents with PCOS and 26 age-matched controls.InterventionsFasting venous blood samples and an oral glucose tolerance test using 75 g of glucose were obtained from PCOS patients and controls.Main Outcome MeasuresClinical features were summarized. Serum levels of FSH, LH, E2, TT, SHBG, fasting insulin, and fasting glucose were measured.ResultsThe prevalence of obesity in adolescents with PCOS was 27% (25/91). 99% of these patients presented with menstrual disorders, 84% presented with clinical and/or biochemical hyperandrogenism, and 90% exhibited an ultrasonographic appearance of polycystic ovaries. The prevalence of hirsutism and acanthosis nigricans were higher in the obese PCOS group than in the nonobese PCOS group (72% vs 41% and 44% vs 5%, respectively). A total of 5 of 20 obese (25%) and 5 of 36 nonobese patients (14%) demonstrated impaired glucose tolerance levels.ConclusionsChinese adolescents with PCOS manifest clinical and metabolic features similar to those of adult Chinese women with PCOS except for the increased prevalence of hyperandrogenism and insulin resistance. Adolescents with high risk factors, especially those with menstrual disorders and hyperandrogenism, may need careful clinical screening.