Use of Autologous Platelet Gel in Female Pelvic Organ Prolapse Surgery: A Feasibility Study

Study ObjectiveWe sought to evaluate whether autologous platelet gel (APG) application during anterior colporrhaphy could increase collagen content of the pubocervical fascia and thereby create a more durable repair.DesignProspective cohort study (Canadian Task Force classification II-2).SettingUniversity hospital.PatientsNine patients undergoing anterior colporrhaphy.InterventionsWe applied APG to the surgical site during anterior colporrhaphy in 9 patients. We collected biopsy specimens from the anterior vaginal wall at surgery and 3 months postoperatively. Collagen content was measured and compared. We evaluated objective and subjective failure rates at 20 months postoperatively.Measurements and Main ResultsNo significant increase occurred in collagen content at 3 months. Subjective failure rate was 12.5%, objective failure rate was 66.7%, and 1 (12.5%) patient required reoperation 10 months postoperatively.ConclusionThe application of APG during anterior colporrhaphy does not seem to increase collagen content or durability of the surgical repair.