کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3959987 1255478 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vulvar Ulcers in Young Females: A Manifestation of Aphthosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Vulvar Ulcers in Young Females: A Manifestation of Aphthosis
چکیده انگلیسی

Study ObjectiveTo examine the etiology, clinical course, and outcomes of non-sexually transmitted vulvar ulcers in young females.DesignA prospective cohort study of subjects referred to a tertiary center who had active vulvar ulcers and no evidence of sexually transmitted infections were evaluated with a structured clinical and laboratory protocol and followed with visits or telephone calls.ResultsTwenty eligible subjects had a mean age of 14 years (range 10–19), and five were premenarchal. Nineteen reported systemic symptoms such as fever, malaise, and headache. Most ulcers were >1cm in diameter (range 0.3–5 cm) and were located on the medial aspect of the labia minora. All viral, bacterial, and fungal cultures were negative. Serologic testing for Epstein-Barr virus (EBV) infection demonstrated 10 subjects with evidence of prior infection, two with acute infection, one indeterminate, and seven negative for infection. Two subjects had evidence of possible acute cytomegalovirus (CMV) infection. Other laboratory findings were nonspecific. The median duration of pain was 10 days (range 6–30), and 75% healed by 21 days. Follow up was available for 19 subjects (median 14 months). Seven experienced recurrent ulcers 2–16 months after the initial episode, and 10 had experienced oral aphthous ulcers. None met criteria for other etiologies of vulvar ulcers reported in the literature.ConclusionsNo single infectious agent was identified as a cause of vulvar ulcers. Most cases were not temporally associated with either acute EBV or CMV infection. These ulcers are consistent with aphthous major or complex aphthosis that arise in response to acute illness.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric and Adolescent Gynecology - Volume 19, Issue 3, June 2006, Pages 195–204
نویسندگان
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