کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3960730 | 1255544 | 2014 | 11 صفحه PDF | دانلود رایگان |
ObjectiveTo investigate clinical outcomes in patients who were at more precise criteria risks for fertilization failure and were treated with selective, short-term fertilization (oocytes and sperm co-incubated for 4 h) and early rescue intracytoplasmic sperm injection (ICSI).MethodsA retrospective analysis was performed on 2 023 women undergoing assisted reproductive technology (ART). They were assigned to 4 groups: short-term in vitro fertilization (short-term IVF, group A, n=217), regular IVF (oocytes and sperm co-incubated overnight, group B, n=1 475), short-term IVF and early rescue ICSI (short-term ICSI, group C, n=94), and regular ICSI (group D, n=237).ResultsIn group A, 69.8% (217/311) achieved normal fertilization rates, and the complete fertilization failure rate (fertilization rate was 0%) was 12.9% (40/311). But all of the fertilization failure oocytes got rescue ICSI. In group B, the complete fertilization failure rate was 1.1% (19/1 692). The fertilization rate, 2 PN (pronucleus) rate, and 1 PN rate were significantly lower in group A than those in group B (70.9% vs 80.8%, 57.8% vs 66.3%, and 3.5% vs 6.2%, respectively). No significant differences were observed in clinical pregnancy rates and birth defect rates between groups A and B. The fertilization rates in groups C and D did not significantly differ (77.9% vs 76.2%), which was also true for birth defect rates. The clinical pregnancy rate of group C was higher than that of group D (51.2% vs 42.3%), but this difference was not significant (P>0.05).ConclusionThese results suggested that selective, short-term fertilization can result in effective outcomes for patients who were at high risk for fertilization failure.
Journal: Journal of Reproduction and Contraception - Volume 25, Issue 4, December 2014, Pages 207-217