کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3963158 | 1255696 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression and Significance of Prosaposin (PSAP) in A Rat Model of Letrozole-induced Polycystic Ovary Syndrome
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Expression and Significance of Prosaposin (PSAP) in A Rat Model of Letrozole-induced Polycystic Ovary Syndrome Expression and Significance of Prosaposin (PSAP) in A Rat Model of Letrozole-induced Polycystic Ovary Syndrome](/preview/png/3963158.png)
چکیده انگلیسی
ObjectiveTo investigate the prosaposin (PSAP) expression in polycystic ovaries.MethodsThe expression of PSAP was examined using immunohistochemistry, quantitative RT-PCR and Western blotting in a rat model with letrozole-induced polycystic ovary syndrom (PCOS).ResultsLetrozole-induced PCOS rat models were similar to those in human PCOS in endocrine disturbances, metabolic characteristics and morphology features. And in these models both mRNA and protein levels of PSAP were significantly increased.ConclusionPSAP was overexpressed in the letrozole-induced PCOS rat model and might play an important role in the occurance and development of PCOS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Reproduction and Contraception - Volume 24, Issue 2, June 2013, Pages 67-75
Journal: Journal of Reproduction and Contraception - Volume 24, Issue 2, June 2013, Pages 67-75