Association of Genetic Polymorphisms of Anti-Müllerian Hormone (AMH) and Its Type II Receptor with Ovarian Hyperstimulation Syndrome

ObjectiveTo explore the association of genetic polymorphisms in the genes encoding the anti-Müllerian hormone (AMH) and its type II receptor (AMHRII) with ovarian hyperstimulation syndrome (OHSS).MethodsUsing polymerase chain reaction (PCR) and DNA sequencing techniques, the exons of AMH and AMHRII were analyzed in 27 OHSS patients (OHSS group) and 22 non-OHSS patients (control group) who were applied controlled ovarian hyperstimulation (COH). Single nucleotide polymorphisms (SNPs) were also analyzed.ResultsSNPs G>T at position 146 of AMH exon 1 and G>A at position 134 of AMH exon 2 showed significant differences between the OHSS group and control group (P<0.05). SNP G>T at position 303 of AMH exon 1 showed no significant difference between the OHSS group and control group (P>0.05). No SNP was detected from the AMHR II exons 1 to 11 in either groups.ConclusionsGenetic polymorphisms in the AMH gene may be a cause of ovarian hypersensitivity to exogenous hormone stimulation and the development of OHSS.