Releasing of Cupric Ion of Three types of Copper-bearing Intrauterine Contraceptive Device in Simulated Uterine Fluid

ObjectiveTo compare the cupric ion releasing in vitro of the three IUDs.MethodsThe stability of cupric ion releasing of IUDs including TCu 380A IUD (TCu 380A), Multiload Cu375 IUD (MCu 375) and Yuangong 365 copper-bearing indomethacin-releasing IUD (Yuangong 365) by the determination of cupric ion releasing in simulated uterine fluid. The simulated uterine fluid was used for releasing media. Copper ion was determined by flame atomic absorption spectrometer.ResultsThe cupric ion releasing of three IUDs were instable at the beginning and tend to be stable gradually. In the stable phase, the average level of cupric ion releasing of TCu380A, MCu375 and Yuangong 365 were 4.25±2.71-7.62±6.42 μg, 4.92±1.23-8.62±3.08 μg and 2.19±0.40-4.68±1.66 μg, respectively. TCu380A had higher instable releasing level than those of Yuangong 365 (P<0.05).ConclusionTCu 380A and MCu 375 showed a “burst release” during the first few days and the former was of great significance(P<0.05). The initial cupric ion releasing of Yuangong 365 appeared to be the lowest, followed by MCu375 and TCu380A in a releasing order.