Comparison of Preliminary Clinical Efficacy for Two Cervical Preparations for Early Second-trimester Pregnancy Termination at 12-17 Weeks Gestation

ObjectiveTo compare clinical efficacy for two cervical preparations for early second-trimester pregnancy termination at 12-17 weeks gestation.MethodsSeventy healthy women aged 18-41 years requesting legal termination of pregnancy at 12-17 weeks of gestation were equally randomized into two groups. Two cervical preparations, the Dilapan-S™ combined with mifepristone and misoprostol (DMM) method, and the mifepristone combined with misoprostol (MM) method, were used to end early second-trimester pregnancy for group DMM and group MM, respectively. Clinical outcomes and complications for these two methods were compared.ResultsNo differences were found on rates of successful abortion within 48 h and blood loss after abortion at 2 h between the two groups (P>0.05). DMM group had significant shorter induction-to-abortion interval and hospital stay compared with group MM (P<0.01). In both DMM and MM groups, side effects including nausea/vomiting, diarrhea, chills and rigors, and fever occurred, and incidences of these side effects were no difference (P>0.05).ConclusionDMM method would have similar clinical efficacies with MM method for early second-trimester pregnancy termination. Besides, DMM method has shorter induction-to-abortion interval and hospital stay, which benefits its clinical application.