کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3964118 | 1255787 | 2015 | 8 صفحه PDF | دانلود رایگان |
ObjectiveTo study clinical significance and the difference of calcitonin receptor stimulating peptide-3 (CRSP-3) expression in placenta tissue between normal pregnancies and patients with preeclampsia.MethodsCRSP-3 expression position in placenta tissues of 50 cases with preeclampsia (preeclampsia group: 25 cases of mild preeclampsia and 25 cases of severe preeclampsia) and 30 cases of normal late pregnancy (control group) was detected using immunohistochemical methods. CRSP-3 mRNA and protein expression in placenta tissues was detected using Real-time PCR and Western blotting method.ResultsSyncytiotrophoblast and cytotrophoblast cells expressed CRSP-3 in placenta tissue of preeclampsia and normal pregnancy patients. The expression levels of CRSP-3 mRNA and protein in placenta tissue of preeclampsia patients were higher than those in control group (P<0.05). The expression levels of CRSP-3 mRNA and protein in placenta tissue of severe preeclampsia patients were higher than those in control group (P<0.01) significantly. The expression level of CRSP-3 mRNA and protein in placenta tissue of severe preeclampsia group was slightly higher than that in mild preeclampsia group, but there were no statistical differences between the two groups (P>0.05).ConclusionThe up-regulation of CRSP-3 in placenta of preeclamptic patients may be associated with the etiology of preeclampsia, but may have no relation with progress and degree of preeclampsia.
Journal: Journal of Reproduction and Contraception - Volume 26, Issue 4, December 2015, Pages 205-212