کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3965180 1255890 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Part 1: Hormone Replacement for Survivors of Childhood Cancer with Ovarian Failure—When Is It Worth the Risk?
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Part 1: Hormone Replacement for Survivors of Childhood Cancer with Ovarian Failure—When Is It Worth the Risk?
چکیده انگلیسی

Survivors of childhood cancer represent a rapidly growing population of patients, some of whom experience temporary or permanent premature ovarian failure (POF) as a consequence of their disease or treatment. Although the risks and benefits of exogenous hormones have been extensively explored in menopausal women 50 years of age and older, there is scant data on the long-term safety of exogenous hormones in childhood cancer survivors. Although there are certainly benefits that can be achieved through hormone replacement for this unique population, many of these patients also have very long hormone exposure times and a markedly increased baseline risk for second malignancies, including breast cancer. Given the significant potential risks, hormone replacement should not be reflexively instituted in childhood cancer survivors with POF. It should only be considered following a thorough, balanced discussion of the risks and benefits of hormone replacement with each patient.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric and Adolescent Gynecology - Volume 24, Issue 2, April 2011, Pages 98–101
نویسندگان
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