Recurrent miscarriage

Miscarriage is one of the most common complications of pregnancy; 15% of clinically recognized pregnancies end in miscarriage. The major cause of spontaneous miscarriage is genetic or developmental abnormalities of the fetus. Recurrent miscarriage occurs in 3% of the population and has been associated with thrombophilia, cervical weakness, infection, and endocrine, anatomical and immune factors. Treatments to prevent miscarriage remain largely untested by randomized controlled trials or evidence-based practice. The resulting consequences have been disappointing for both patients and health-care providers. This article is therefore designed to enhance critical thinking and improve clinical skills in an area with an extensive and contradictory literature.