Management of Atypical Glandular Cells and Adenocarcinoma in Situ

Glandular abnormalities of the cervix remain a difficult clinical problem. It is a challenge for the clinician to manage and follow this unusual cytologic finding properly. This article highlights the definitions of glandular abnormalities, reviews current published guidelines for clinical management, and discusses the underlying rates of neoplasia associated with these cytology reports. It reviews proper follow-up of patients found not to have neoplasia and current treatment options for patients who have significant neoplasia. It also discusses the diagnosis of associated endometrial lesions and the use of human papillomavirus DNA testing in the management of glandular lesions of the lower genital tract.