کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3970286 1256715 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anogenital distance of women in relation to their mother’s gynaecological characteristics before or during pregnancy
ترجمه فارسی عنوان
فاصله آنومالی زنان نسبت به ویژگی های زنان مادر قبل و یا در دوران بارداری
کلمات کلیدی
آندروژن ها، فاصله کانونی، چرخه های نامنظم، قرار گرفتن در معرض، دستگاه تناسلی زنان
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی

Animal models suggest that anogenital distance (AGD) at birth reflects androgen concentrations during in-utero development and predicts adult AGD. Several human observational studies show an association between menstrual cycle irregularities and a hyperandrogenic environment and that may result in a potential alteration of the female reproductive tract during in-utero development. This study examined associations between AGD of young women and their mother’s gynaecological characteristics before or during pregnancy. This is cross-sectional study of 100 college-age volunteers in southern Spain. Physical and gynaecological examinations were conducted on the young women and they and their mothers completed epidemiological questionnaires on lifestyles and gynaecological history. Linear regression analysis was used to examine the association between AGD measurements (anus–fourchette (AGDAF) and anus–clitoris (AGDAC)) of women and their mother’s gynaecological characteristics. Longer AGDAF was associated with the presence of mother’s menstrual cycle irregularities before pregnancy (P = 0.03). Longer female AGD has been related to excess androgen exposure in utero in toxicological studies. The current findings may be consistent with studies in which an association between menstrual cycle irregularities and an hyperandrogenic environment has been reported, which therefore may result in a potential modification of the female offspring’s reproductive tract during in-utero development, including AGD.Rodent models suggest that perineal length at birth reflects male hormone concentrations (androgens) during in-utero development and predicts adult perineal length. Several human studies show a relationship between menstrual cycle irregularities and an excessive androgen environment. We hypothesize that androgen excess may result in a potential alteration of the female reproductive tract during in-utero development. Our aim was to examine associations between perineal length of young women and their mother’s gynaecological characteristics before or during pregnancy. This is a study of 100 college-age volunteers in Southern Spain. Physical and gynaecological examinations were conducted on the young women and they and their mothers completed epidemiological questionnaires on lifestyles and gynaecological history. We used multivariate analyses to assess the association between perineal length of women and their mother’s gynaecological characteristics. Longer perineal length was associated with the presence of mother’s menstrual cycle irregularities before pregnancy. Longer female perineal length has been related to excess androgen exposure in utero in rodent studies. Our findings may be consistent with previous studies in which an association between menstrual cycle irregularities and an excess of androgen has been reported, which therefore may result in a potential modification of the female offspring’s reproductive tract during in-utero development, including perineal length.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive BioMedicine Online - Volume 28, Issue 2, February 2014, Pages 209–215
نویسندگان
, , , , , , ,