کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3971311 | 1256760 | 2009 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Morphogenesis of polycystic ovaries as assessed by pituitary–ovarian androgenic function Morphogenesis of polycystic ovaries as assessed by pituitary–ovarian androgenic function](/preview/png/3971311.png)
Despite polycystic ovaries (PCO) being a common morphology in women with polycystic ovary syndrome and regular menstruation, the regulatory principles in the morphogenesis of antral follicles have not yet been elucidated. In recognition of the complementary interaction between androgen-induced expression of the FSH receptor and FSH-augmented expression of the androgen receptor in granulose cells of antral follicles, a possible correlation of antral follicle count (AFC) and pituitary–ovarian androgenic function was investigated in 180 infertile women over days 3–5 of the menstrual cycle. Six discrete types of PCO with decreasing pituitary–ovarian androgenic function were identified: Type I (classical Stein–Leventhal syndrome), Type II (hyperandrogenemism), Type III (singular hyper-LH), Type IV (cryptic hyperandrogenism), Type V (relative LH dominancy) and Type VI (relative FSH dominancy), in parallel to a diminishing number of AFC from Type I to Type VI. Because during the early follicular phase of the cycle until the selection of the dominant follicle, antral follicles are composed of newly emerged healthy follicles plus atretic antral follicles that remain non-ovulated from previous cycles, it is proposed that the six types of PCO may represent the folliculogenetic spectra along which PCO morphogenesis proceeds.
Journal: Reproductive BioMedicine Online - Volume 18, Issue 5, 2009, Pages 635-643