کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3971827 | 1256781 | 2009 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: From ultrastructural flagellar sperm defects to the health of babies conceived by ICSI From ultrastructural flagellar sperm defects to the health of babies conceived by ICSI](/preview/png/3971827.png)
The objective of this retrospective study was to describe a population of patients displaying impaired sperm motility due to ultrastructural flagellar defects and to analyse the intracytoplasmic sperm injection (ICSI) results and neonatal outcomes in this population. The fertilization rate, embryo quality, clinical pregnancy rate, implantation rate, birth rate and perinatal health of babies were determined. Patients (n = 20) were divided into seven categories according to ultrastructural flagellar abnormalities. The type of flagellar abnormality significantly affected the fertilization rate (P < 0.025). Two types of flagellar abnormalities showed slower early embryo cleavage kinetics (P < 0.001) when axonemal central structures and periaxonemmal columns were abnormal or absent. Of 53 ICSI attempts, 14 resulted in clinical pregnancies (26.4% per cycle) after fresh and frozen embryo transfer. Three (21.4%) of these pregnancies ended in miscarriages and, in the remaining, 12 infants were born (7.2% of transferred embryos). The outcomes differed according to the ultrastructural defect. This study demonstrates that a high proportion of patients could father a child (45.0%). However, flagellar abnormalities appear to influence ICSI results and fetal development.
Journal: Reproductive BioMedicine Online - Volume 19, Issue 3, 2009, Pages 326-336