کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3972433 | 1256810 | 2009 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Oestrogenic regulation and differential expression of WNT4 in the bonnet monkey and rodent epididymis Oestrogenic regulation and differential expression of WNT4 in the bonnet monkey and rodent epididymis](/preview/png/3972433.png)
A role for oestrogen in regulating fluid reabsorption in the monkey epididymis was recently demonstrated. Here, these studies are extended to identify potential oestrogen-regulated proteins in the cauda region of monkey epididymis treated with vehicle and oestrogen receptor antagonist (ICI 182780). Two-dimensional electrophoretic analysis was used to identify the proteins. The results indicated down-regulation of WNT4 in the ICI-182780-treated monkey cauda. In addition, the Wnt4 mRNA concentration was also reduced in the caput regions of ICI-182780-treated rats and oestrogen receptor knockout mice. WNT4 is a key regulator of gonadal differentiation in humans and mice and plays a pivotal role in early mouse embryogenesis. The results of the present study establish the presence of WNT4 in the monkey epididymis and its regulation by oestrogen, and suggest a role for WNT4 in maintaining epididymal homeostasis.
Journal: Reproductive BioMedicine Online - Volume 18, Issue 4, 2009, Pages 555-561