کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3972591 | 1256816 | 2008 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Underlying karyotype abnormalities in IVF/ICSI patients Underlying karyotype abnormalities in IVF/ICSI patients](/preview/png/3972591.png)
Cytogenetic investigations are performed in couples asking for IVF or intracytoplasmic sperm injection (ICSI) treatment. These serve a diagnostic purpose because male or female infertility might have a chromosomal origin. Chromosomal aberrations found in these patients include numerical abnormalities, such as Klinefelter syndrome, XYY karyotype or Turner syndrome and its variants; sex reversions, such as XX males or XY females; and also structural abnormalities, such as Robertsonian or reciprocal translocations and inversions. Finding the chromosomal origin of infertility in a patient also has a prognostic value because it aids the management of pregnancies obtained after IVF or ICSI and may lead to a proposal of prenatal or preimplantation genetic diagnosis.
Journal: Reproductive BioMedicine Online - Volume 16, Issue 4, 2008, Pages 514-522