کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3972859 | 1256829 | 2007 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Mutations along the hypothalamic–pituitary–gonadal axis affecting male reproduction Mutations along the hypothalamic–pituitary–gonadal axis affecting male reproduction](/preview/png/3972859.png)
Disorders in male reproductive function are caused by mutations of key genes at all levels of the hypothalamic–pituitary–testicular axis. They may affect the ontogeny and function of the hypothalamic centres governing gonadotrophin synthesis and secretion, the development of the anterior pituitary gland, the production of gonadotrophins and the function of their receptor genes, and finally the genes responsible for testicular hormone production and gametogenesis. This review focuses on mutations that affect the synthesis and secretion of hypothalamic gonadotrophin-releasing hormone, pituitary follicle-stimulating hormone and luteinising hormone, as well as their testicular receptors, thus covering a selected group of genetic causes of hypo- and hypergonadotrophic male hypogonadism.
Journal: Reproductive BioMedicine Online - Volume 15, Issue 6, 2007, Pages 622-632