T cells in normal pregnancy and recurrent pregnancy loss

This review focuses on the possible role of T cells in successful pregnancy and in unexplained recurrent abortion. The functions exhibited by Th1 and Th2 cells have suggested, perhaps in a simplistic way, that Th1-type cytokines, which promote allograft rejection, may compromise pregnancy, whereas the Th2-type cytokines, by inhibiting Th1 responses, promote allograft tolerance and therefore may improve fetal survival. However, Th1 cytokines are not always detrimental for pregnancy development. Th1 cytokines, depending on their time of expression, stage of gestation and relative concentrations, could have a positive role in successful pregnancy. Other cytokines (LIF, M-CSF) produced by T cells seem to be important for the maintenance of pregnancy. Hormones present in the microenvironment of the decidual T cells could be responsible, at least in part, for the cytokine profile of the T cells. Indeed, progesterone is a potent inducer of Th2-type cytokines (e.g. IL-4 and IL-5), LIF and M-CSF production by T cells, whereas relaxin induces T cells to produce IFNγ. Of course, the success of pregnancy depends on many mechanisms induced by different type of cells. Th2 cells could be one of these.