کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3974811 1257023 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SIRS and group-B streptococcal sepsis in newborns: Pathogenesis and perspectives in adjunctive therapy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
SIRS and group-B streptococcal sepsis in newborns: Pathogenesis and perspectives in adjunctive therapy
چکیده انگلیسی

SummaryClinical signs of systemic inflammation and suspected systemic infection are common in neonatal medicine. Yet, causative infectious organisms can only infrequently be isolated. In previously healthy infants at low risk of sepsis, group B streptococcus (GBS) is the most common isolate. In vitro and in vivo data suggest that immune cells from newborn infants have impaired antimicrobial properties against GBS. In contrast large amounts of inflammatory mediators are formed upon GBS challenge and Toll-like receptors (TLR) are critical host molecules in this context. Thus, the immune balance tilts towards inflammation, SIRS and sepsis. Adjunctive therapy of neonatal sepsis needs to adjust the inflammatory response without further impairing bacterial clearance. This article summarises the pathophysiological events leading to sepsis and suggests molecular targets for adjunctive therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Fetal and Neonatal Medicine - Volume 11, Issue 5, October 2006, Pages 333–342
نویسندگان
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