کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3975248 1600969 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Investigation of the impact of antinuclear antibody on the outcome of in vitro fertilization/intracytoplasmic sperm injection treatment
ترجمه فارسی عنوان
بررسی تاثیر آنتی بادی ضد سرطانی بر نتایج حاصل از لقاح داخل وریدی / تزریق داخلسیوپاتالاسمی اسپرم
کلمات کلیدی
آنتی بادی های ضد انسداد، آزمایش خون ایمپلنت، آزمایش ایمنی فلوئورسانس غیر مستقیم، ناباروری، لقاح آزمایشگاهی / تزریق اسپرم داخلسیوپاتالاسمی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی

ObjectiveThe aim of this study is to investigate the influence of antinuclear antibodies (ANAs) on the pregnancy and early miscarriage rates, thereby evaluating the outcome of in vitro fertilization and intracytoplasmic sperm injection (IVF/ICSI) treatment.Materials and methodsA total of 517 infertile female patients undergoing IVF/ICSI treatment (experimental group) were chosen for this study, and 186 women with normal reproductive history (control group) were designated as the control. Serum ANAs from the participants were tested using indirect immunofluorescence assay, while antiextractable nuclear antigens were tested by immune blot assay.ResultsThe ANA expression in the infertile patients (39.45%) was higher than that in the control group (16.13%). A high ANA titer (≥1:320) was found only in infertile patients. ANA positivity significantly decreased the pregnancy rate and increased the early miscarriage rate after IVF/ICSI treatment. The rate of early miscarriage was higher in the high-ANA-titer individuals after IVF/ICSI treatment. Clinical pregnancy rate in anti-scl-70- and anti-PM-scl-positive individuals after IVF/ICSI treatment was lower than that in the ANA-negative individuals. Anti-Rib-p, anti-Jo-1, and anti-dsDNA were found to cause high risk of early miscarriage in pregnant women.ConclusionANA positivity may not only be the cause of bad outcome during IVF/ICSI treatment, but also pose as a risk factor for IVF/ICSI treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Taiwanese Journal of Obstetrics and Gynecology - Volume 54, Issue 6, December 2015, Pages 742–748
نویسندگان
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