Successful Treatment of Primary Vaginal Diffuse Large B-Cell Lymphoma Using Chemotherapy

SummaryObjectiveNon-Hodgkin's lymphomas (NHL) rarely affect the vagina. As a result, a standard treatment has not been defined.Case ReportA 34-year-old female virgin patient with a primary vaginal NHL stage IEA, diffuse large cell B lineage, showed an excellent response to cytotoxic chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone) without surgery or radiotherapy. She had experienced no recurrence after 40 months.ConclusionIn young patients who wish to preserve their fertility, chemotherapy alone may be the treatment of choice for primary diffuse large B-cell NHL of the lower female genital tract.