Synthesis, characterization and catalytic properties of magnetic nanoparticle supported guanidine in base catalyzed synthesis of α-hydroxyphosphonates and α-acetoxyphosphonates

• MNPs-Guanidine was synthesized and characterized as an interphase basic nanocatalyst.
• It was used for the synthesis of α-hydroxyphosphonates and α-acetoxyphosphonates.
• The catalyst allows for greener methodologies while keeping high reaction yields and low reaction times.
• The catalyst was easily recovered and reused without any significant loss in catalytic activity.
• Superiority of the catalyst in comparison with the reported catalysts was investigated.

Magnetic nanoparticle Fe3O4-immobilized guanidine (MNPs-Guanidine) as a novel magnetically interphase nanocatalyst was synthesized and characterized. MNPs-Guanidine catalyzed the synthesis of α-hydroxyphosphonates from aldehydes and dimethyl phosphite in solvent-free condition at 80 °C. The synthesis of α-acetoxyphosphonates through a one-pot reaction of aldehydes, dimethyl phosphite and acetic anhydride was also achieved using this catalyst in PEG at room temperature. The catalyst was recycled up to 10 times with little loss of activity.

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