Intravitreal Injection Anesthesia-Comparison of Different Topical Agents: A Prospective Randomized Controlled Trial

There was no clinical difference in patient pain experience between the 3 anesthetic options tested. The addition of a 4% lidocaine pledget offered no clinical advantage in pain relief compared to 0.5% tetracaine or 4% cocaine (+ epinephrine 1/100 000) drops alone.