Bilateral Abnormalities of Optic Nerve Size and Eye Shape in Unilateral Amblyopia

Unilateral amblyopia is associated with bilaterally, but also with subclinically hypoplastic ONs, greater than normal AL/ON, and abnormally noncircular globe cross-section. These factors evidently do not determine which of the 2 eyes will become amblyopic. Reduced circularity of amblyopic and fellow eyes may reflect optical causes of amblyopia or bilateral dysregulation of globe shape secondary to amblyopia.