Inter-device Variability of the Stratus Optical Coherence Tomography

We did not observe statistically significant differences in any macular and all but one RNFL parameter between the four Stratus OCT machines. Signal strength was significantly different between the machines, and significantly correlated with some RNFL parameters. Inter-machine variability in RNFL measurements may have clinical significance. Signal strength should be included in the assessment of measurements obtained on different machines and in serial examinations with a single Stratus machine during patient follow-up.