Effect of Signal Strength and Improper Alignment on the Variability of Stratus Optical Coherence Tomography Retinal Nerve Fiber Layer Thickness Measurements

Even under optimal testing conditions, scan quality can adversely effect the ability to detect change over time. Therefore, caution is warranted when detecting glaucomatous progression using scan series of different quality. Careful overall assessment of quadrants and average RNFL thickness measurements is suggested to help identify scan misalignment.