In Vitro Evaluation of Combination Antifungal Activity against Fusarium Species Isolated from Ocular Tissues of Keratomycosis Patients

Amphotericin B plus terbinafine or itraconazole demonstrated more effective anti-Fusarium species activity than single-use in vitro treatment, which implies that these combinations may be helpful in treating fungal keratitis. The combinations of natamycin plus azoles or natamycin plus terbinafine were not satisfactory and can be avoided. Further in vivo studies are needed to elucidate the potential usefulness of these combination therapies.