LOC387715/HTRA1 Variants in Polypoidal Choroidal Vasculopathy and Age-related Macular Degeneration in a Japanese Population

The LOC387715/HTRA1 variants are associated with PCV and wet AMD in the Japanese population. The associations are stronger in AMD than in PCV. PCV and AMD share common genetic factors, which suggests that PCV and wet AMD are similar in some pathophysiologic aspects.