Ionic liquid immobilized on γ-Fe2O3 nanoparticles: A new magnetically recyclable heterogeneous catalyst for one-pot three-component synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines

• Ionic liquid immobilized on γ-Fe2O3 magnetic nanoparticles was synthesized.
• It was used as a heterogeneous catalyst for the synthesis of pyridine derivatives.
• Pyridine derivatives were obtained in good to high yields.
• In this method, catalyst separation was easily performable by a magnetic bar.
• This catalyst was reused at least five times with sustained catalytic activity.

2-Hydroxyethylammonium sulphonate immobilized on γ-Fe2O3 nanoparticles (γ-Fe2O3-2-HEAS) was synthesized as a new supported ionic liquid by the reaction of n-butylsulfonated γ-Fe2O3 with ethanolamine. It was used as a magnetically recyclable heterogeneous catalyst for the efficient one-pot, three-component synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines. The catalyst was easily isolated from the reaction mixture by magnetic decantation using an external magnet and reused at least five times without significant degradation in the activity.

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