Relationship of slow-phase velocity to visual acuity in infantile nystagmus associated with albinism

PurposeTo investigate the relationship between slow-phase velocity of nystagmus and visual acuity in children with albinism.MethodsTwelve children with infantile nystagmus associated with albinism had eye movements recorded by binocular video-oculography (10 patients) or by scleral search coil (2 patients). In children younger than 3 years of age visual acuities was assessed by means of Teller acuity cards and corrected for age. Histograms of horizontal eye velocities were fit by a gamma distribution in all patients (r2 > 0.85). The velocity at the peak of the gamma distribution was compared with the limiting velocity predicted by the dynamic visual acuity (DVA) model.ResultsAll histograms of slow-phase eye velocity were skewed toward lower velocities, with the peak distribution ranging from 5 to 20 degrees/second. The velocity at the peak of the gamma distribution for each subject was uniformly equal to or below the limiting velocity predicted by the DVA model. The average of the gamma distribution across all subjects corresponded to an upper limit to eye velocity of 17 degrees/second. At this velocity the DVA model predicted visual acuity of 20/50, which is lower than the average visual acuity reported in albinism. The distributions of eye velocity were lower than the limiting eye velocity predicted on the basis of DVA almost 50% of the time.ConclusionsVisual acuity in albinism is limited by macular hypoplasia rather than by slow-phase eye velocity of nystagmus.