Clinicopathological correlation of 3 patterns of calcification in a hydrophilic acrylic intraocular lens

We present 3 cases of opacification in the Biocomfold 92S intraocular lens (IOL), with a documented increase in the opacification over time in 1 case. Histopathological analysis revealed the opacification was caused by calcification in the IOL's optic material. The pattern of calcium deposition, however, was different in each IOL. The causative mechanisms for this complication are unclear. Further research is warranted.