کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4025870 1262407 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Longitudinal Changes in Peripapillary Atrophy in the Ocular Hypertension Treatment Study : A Case–Control Assessment
ترجمه فارسی عنوان
تغییرات طولی در آتروفی پرپاپیلی در مطالعه درمانی فشارخون چشم: یک بررسی کیفی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی چشم پزشکی
چکیده انگلیسی

PurposeTo explore the association between peripapillary atrophy (PPA) area and conversion from ocular hypertension (OHT) to glaucoma.DesignProspective, longitudinal cohort study of cases and controls.ParticipantsWe included 279 age-matched and follow-up time–matched eyes with OHT that converted to glaucoma and 279 eyes with OHT that did not convert to glaucoma.MethodsInitial and last acceptable optic disc photos were analyzed. Disc, α-zone, and β-zone PPA were traced independently by 2 trained readers and their areas were measured with Photoshop. The α-zone and β-zone areas were expressed as a percentage of optic disc area.Main Outcome Measuresα-Zone and β-zone PPA size over time.ResultsIntraclass correlation coefficients (ICCs) demonstrated that readers had good agreement on disc area (ICC = 0.97) and β-zone (ICC = 0.82), but not α-zone (ICC = 0.48). The ß-zone, as a percentage of disc area, increased in size (P < 0.001) in both eyes with incident primary open-angle glaucoma (mean, 10.6%; standard deviation, 22.6%) and matched controls (mean, 10.1%; standard deviation, 33.7) over follow-up (mean, 12.3 years). The increase in size did not differ between cases and controls (P = 0.82). Enlargement of the β-zone was not correlated with follow-up time (P = 0.39).ConclusionsThe results did not show a difference in size of the β-zone at baseline between eyes that proceed to develop glaucoma and those that do not. Moreover, the β-zone enlarges equally in case and control eyes during follow-up.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ophthalmology - Volume 122, Issue 1, January 2015, Pages 79–86
نویسندگان
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