Hyperreflective Sign in Resolved Cotton Wool Spots Using High-Resolution Optical Coherence Tomography and Optical Coherence Tomography Ophthalmoscopy

Acute CWSs show a hyperreflective pattern on OCT. As they become ophthalmoscopically invisible, the OCT still shows signs of hyperreflectivity in the areas of previous CWSs (hyperreflective sign). The authors observed the same phenomenon using 2 imaging machines.