Polymorphisms within the Tumor Necrosis Factor-α Promoter Region in Patients with HLA-B27-Associated Uveitis

Our data suggest that HLA-B27-positive individuals show a higher susceptibility towards development of an intraocular inflammation in the presence of an A allele at nucleotide -238 and, to a lesser degree, at nucleotide -308 of the TNF-α gene promoter.