کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4032041 1262938 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intravitreal therapy for neovascular age-related macular degeneration and inter-individual variations in vitreous pharmacokinetics
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های حسی
پیش نمایش صفحه اول مقاله
Intravitreal therapy for neovascular age-related macular degeneration and inter-individual variations in vitreous pharmacokinetics
چکیده انگلیسی

This article aims to provide an interpretation and perspective on current concepts and recent literature regarding the evidence for individualizing intravitreal therapy (IVT), particularly considering iatrogenic and patient factors in the management of neovascular age-related macular degeneration (AMD). As ocular parameters that govern IVT pharmacokinetics do vary between individuals with AMD, developing a personalized strategy could improve safety and efficacy. This has to be derived from clinical measurements and data from laboratory animals; however, it is recognized that the animal models used in the development of intraocular formulations differ in their vitreous geometry from humans. These factors may be of relevance to the design of ophthalmic formulations and optimizing treatment outcomes in AMD. Further studies are needed to drive improvements in clinical practice which are aimed at maximizing the efficacy profile in IVT for AMD by a more rigorous evaluation of patient and surgeon-related variables.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Retinal and Eye Research - Volume 29, Issue 6, November 2010, Pages 466–475
نویسندگان
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