کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4033091 1603061 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical Safety Profile of Posterior Juxtascleral Depot Administration of Anecortave Acetate 15 mg Suspension as Primary Therapy or Adjunctive Therapy with Photodynamic Therapy for Treatment of Wet Age-Related Macular Degeneration
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی چشم پزشکی
پیش نمایش صفحه اول مقاله
Clinical Safety Profile of Posterior Juxtascleral Depot Administration of Anecortave Acetate 15 mg Suspension as Primary Therapy or Adjunctive Therapy with Photodynamic Therapy for Treatment of Wet Age-Related Macular Degeneration
چکیده انگلیسی

ObjectivesSafety data for anecortave acetate 15 mg suspension (Retaane 15 mg, Alcon Research, Ltd., Ft. Worth, TX 76134) as primary or adjunctive therapy with photodynamic therapy are available for 358 patients with age-related macular degeneration who received this novel cortisene during clinical trials in which the drug was administered via posterior juxtascleral depot every 6 months for 2 years.MethodsDetailed ophthalmic examinations, physical examinations, and adverse event reporting were used to characterize the clinical safety of anecortave acetate 15 mg and were monitored by an Independent Safety Committee.ResultsAnecortave acetate 15 mg was safe and well tolerated in the overall patient population. No serious, treatment-related deaths were reported. Ocular adverse events assessed as related to anecortave acetate 15 mg were non-serious with one exception (retinal detachment), mild to moderate in intensity with one exception, generally resolved with or without treatment, and did not interrupt patient participation in the studies with two exceptions.ConclusionsAnecortave acetate 15 mg is safe and well-tolerated when administered as a posterior juxtascleral depot at 6-month intervals for use as primary therapy or as adjunctive therapy with PDT.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Survey of Ophthalmology - Volume 52, Issue 1, Supplement, January 2007, Pages S70–S78
نویسندگان
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