کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4033201 1603066 2006 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Role of Inflammation in the Pathogenesis of Age-related Macular Degeneration
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی چشم پزشکی
پیش نمایش صفحه اول مقاله
The Role of Inflammation in the Pathogenesis of Age-related Macular Degeneration
چکیده انگلیسی

Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, is a complex disease to study because of the potential role of demographic, environmental, and other systemic risk factors, such as age, sex, race, light exposure, diet, smoking, and underlying cardiovascular disease which may contribute to the pathogenesis of this disease. Recently, single nucleotide polymorphisms, DNA sequence variations found within the complement Factor H gene, have been found to be strongly associated with the development of AMD in Caucasians. One single nucleotide polymorphism, Tyr402His, was associated with approximately 50% of AMD cases. We review recent developments in the molecular biology of AMD, including single nucleotide polymorphisms within the Factor H gene, which may predispose individuals to the susceptibility of AMD as well as single nucleotide polymorphisms that may confer a protective effect. Taken together these findings help to provide new insights into the central issues surrounding the pathogenesis of AMD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Survey of Ophthalmology - Volume 51, Issue 2, March–April 2006, Pages 137–152
نویسندگان
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