Bevacizumab treatment for choroidal neovascularization in a patient with chorioretinopathy resembling presumed ocular histoplasmosis syndrome

Presumed ocular histoplasmosis syndrome (POHS) is rare in Taiwan. We report on a patient with a clinical picture resembling POHS who was successfully treated with intravitreal bevacizumab. A 42-year-old woman had blurred vision of her right eye. Ophthalmological examination revealed multiple juxtapapillary and peripheral punched-out chorioretinal scars. Fluorescein angiography and optic coherence tomography showed subfoveal choroidal neovascularization (CNV). She received three injections of intravitreal bevacizumab. The CNV regressed after treatment. Her visual acuity maintained 20/20 at 1 year follow-up. Taiwan is not an endemic area for histoplasmosis. Clinicians should be cautious in differential diagnosis of the clinical presentation of POHS or similar disease entities. Early identification and timely treatment with intravitreal bevacizumab may rescue the patient from vision loss.