Degeneration of cortical function in the Royal College of Surgeons rat

The purpose of the current study was to determine the progress of cortical functional degeneration in the Royal College of Surgeons (RCS) rat. Cortical responses were measured with optical imaging of intrinsic signals using gratings of various spatial frequencies. Subsequently, electrophysiological recordings were also taken across cortical layers in response to a pulse of broad-spectrum light. We found significant degeneration in the cortical processing of visual information as early as 4 weeks of age. These results show that degeneration in the cortical response of the RCS rat starts before development has been properly completed.

► Royal College of Surgeons rat brain electrophysiology.
► Early degeneration in the cortical processing to gratings stimulation.
► Cortical processing to bright light stimulation is preserved for several months.
► Delay in the response latency within the first month of life.
► Cortical processing degenerates in RCS rat before the visual system reaches maturity.