کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4034815 | 1263484 | 2009 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential effects of charybdotoxin on the activity of retinal ganglion cells in the dark- and light-adapted mouse retina
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differential effects of charybdotoxin on the activity of retinal ganglion cells in the dark- and light-adapted mouse retina Differential effects of charybdotoxin on the activity of retinal ganglion cells in the dark- and light-adapted mouse retina](/preview/png/4034815.png)
چکیده انگلیسی
Patch-clamp recordings were made from retinal ganglion cells in the mouse retina. Under dark adaptation, blockage of BKCa channels increases the spontaneous excitatory postsynaptic currents (EPSCs) and light-evoked On-EPSCs, while it decreases the light-evoked Off inhibitory postsynaptic currents (IPSCs). However, under light adaptation it decreases the light-evoked On-EPSCs, the spontaneous IPSCs and the light-evoked On- and Off-IPSCs. Blockage of BKCa channels significantly altered the outputs of RGCs by changing their light-evoked responses into a bursting pattern and increasing the light-evoked depolarization of the membrane potentials, while it did not significantly change the peak firing rates of light-evoked responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vision Research - Volume 49, Issue 3, February 2009, Pages 388–397
Journal: Vision Research - Volume 49, Issue 3, February 2009, Pages 388–397
نویسندگان
Joseph P. Nemargut, Junling Zhu, Brian T. Savoie, Guo-Yong Wang,