کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4034883 | 1263490 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The capsule drug device: Novel approach for drug delivery to the eye
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Treatment of age-macular degeneration requires monthly intravitreal injections, which are costly and have serious risks. The objective of this study was to develop a novel intraocular implant for drug delivery. The capsule drug ring is a reservoir inserted in the lens capsule during cataract surgery, refillable and capable of delivering multiple drugs. Avastin® was the drug of interest in this study. Prototypes were manufactured using polymethylmethacrylate sheets as the reservoir material, a semi-permeable membrane for controlled delivery and silicone check valves for refilling. The device showed near zero-order release kinetics and Avastin® stability was investigated with accelerated temperature studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vision Research - Volume 50, Issue 7, 31 March 2010, Pages 680–685
Journal: Vision Research - Volume 50, Issue 7, 31 March 2010, Pages 680–685
نویسندگان
Sarah A. Molokhia, Himanshu Sant, Jacquelyn Simonis, C.J. Bishop, R.M. Burr, Bruce K. Gale, Balamurali K. Ambati,