کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4035713 1263544 2007 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Specific alterations of tyrosine hydroxylase immunopositive cells in the retina of NT-4 knock out mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های حسی
پیش نمایش صفحه اول مقاله
Specific alterations of tyrosine hydroxylase immunopositive cells in the retina of NT-4 knock out mice
چکیده انگلیسی

To assess the effect of NT-4 deprivation on maturation of retinal circuitry, we investigated a mouse with targeted deletion of the gene encoding nt-4 (nt-4−/−). In particular, we studied neurons immunostained by an antibody recognizing tyrosine hydroxylase (TH), the rate limiting enzyme for dopamine (DA) synthesis. We found that TH immunopositive processes were altered in the retina of nt-4−/−. Alteration of TH immunopositive processes in nt-4−/− mice resulted in changes of DA turnover, as assessed by high-pressure liquid chromatography measurements. These findings suggest that retinal NT-4 plays a role in the morphological maturation of dopaminergic retinal cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vision Research - Volume 47, Issue 11, May 2007, Pages 1523–1536
نویسندگان
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