کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4035713 | 1263544 | 2007 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Specific alterations of tyrosine hydroxylase immunopositive cells in the retina of NT-4 knock out mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
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چکیده انگلیسی
To assess the effect of NT-4 deprivation on maturation of retinal circuitry, we investigated a mouse with targeted deletion of the gene encoding nt-4 (nt-4−/−). In particular, we studied neurons immunostained by an antibody recognizing tyrosine hydroxylase (TH), the rate limiting enzyme for dopamine (DA) synthesis. We found that TH immunopositive processes were altered in the retina of nt-4−/−. Alteration of TH immunopositive processes in nt-4−/− mice resulted in changes of DA turnover, as assessed by high-pressure liquid chromatography measurements. These findings suggest that retinal NT-4 plays a role in the morphological maturation of dopaminergic retinal cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vision Research - Volume 47, Issue 11, May 2007, Pages 1523–1536
Journal: Vision Research - Volume 47, Issue 11, May 2007, Pages 1523–1536
نویسندگان
Martina Calamusa, Padmanabhan Paranji Pattabiraman, Nikita Pozdeyev, P. Michael Iuvone, Alessandro Cellerino, Luciano Domenici,