کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4035882 1263555 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of HTRA1 polymorphism and bilaterality in advanced age-related macular degeneration
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های حسی
پیش نمایش صفحه اول مقاله
Association of HTRA1 polymorphism and bilaterality in advanced age-related macular degeneration
چکیده انگلیسی

Single nucleotide polymorphism (SNP), rs11200638, in the promoter of HTRA1 has recently been shown to increase the risk for AMD. In order to investigate the association of this HTRA1 polymorphism and the bilaterality of AMD, we genotyped rs11200638 in control, unilateral, and bilateral advanced AMD patients. The A allele for SNP rs11200638 in HTRA1, was significantly more prevalent in bilateral wet AMD and GA patients than in unilateral groups (p = .02 and p = .03, respectively). The homozygote odds ratios of bilateral wet AMD and GA are significantly greater than those seen in unilateral groups (twofold and threefold increase, respectively). This finding is consistent with the role of HTRA1 in AMD pathogenesis and will help aid in the clinical management and prognosis of AMD patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vision Research - Volume 48, Issue 5, February 2008, Pages 690–694
نویسندگان
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