کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
404670 677442 2008 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reversed and forward buffering of behavioral spike sequences enables retrospective and prospective retrieval in hippocampal regions CA3 and CA1
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر هوش مصنوعی
پیش نمایش صفحه اول مقاله
Reversed and forward buffering of behavioral spike sequences enables retrospective and prospective retrieval in hippocampal regions CA3 and CA1
چکیده انگلیسی

We propose a mechanism to explain both retrospective and prospective recall activity found in experimental data from hippocampal regions CA3 and CA1. Our model of temporal context dependent episodic memory replicates reverse recall in CA1, as recently recorded and published [Foster, D., & Wilson, M. (2006). Reverse replay of behavioural sequences in hippocampal place cells during the awake state. Nature, 440, 680–683], as well as the prospective and retrospective activity recorded in region CA3 during spatial tasks [Johnson, A., & Redish, A. (2006). Neural ensembles in ca3 transiently encode paths forward of the animal at a decision point: a possible mechanism for the consideration of alternatives. In 2006 neuroscience meeting planner. Atlanta, GA: Society for Neuroscience. (Program no. 574.2)]. We suppose that CA3 encodes episodic memory of both forward and reversed sequences of perforant path spikes representing place input. Using a persistent firing buffer mechanism in layer II of entorhinal cortex, simulated episodic learning involves dentate gyrus, layer III of entorhinal cortex, and hippocampal regions CA3 and CA1. Associations are formed between buffered episodic cues, unique temporal context specific representations in dentate gyrus, and episodic memory in the CA3 recurrent network.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neural Networks - Volume 21, Issues 2–3, March–April 2008, Pages 276–288
نویسندگان
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