Sulfated tungstate catalyzed selective N-monoalkylation of primary amines with alcohol

We have developed an environmentally benign protocol for N-monoalkylation of primary amines with alcohols using sulfated tungstate as heterogeneous catalyst. Elimination of formation of overalkylated amines as by-products, use of alcohols as alkylating agent has resulted in high atom-economy transformation. In addition efficient, mild reaction conditions, easy product isolation and reusability of the catalyst are attractive features. The developed protocol has been successfully applied for N-monoalkylation of aromatic as well aliphatic amines with different alcohols.

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► Sulfated tungstate is mildly acidic, stable, eco-friendly heterogeneous catalyst.
► The catalyst is easy to prepare and well characterized.
► Efficient for selective N-monoalkylation of primary amines.
► The catalyst can be easily recovered and recycled several times.