کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
408465 679031 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A biophysical model of short-term plasticity at the calyx of Held
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر هوش مصنوعی
پیش نمایش صفحه اول مقاله
A biophysical model of short-term plasticity at the calyx of Held
چکیده انگلیسی

The calyx of Held is a giant glutamatergic synapse in the auditory system and displays multiple forms of short-term facilitation and depression. This study presents a detailed model of short-term plasticity at this synapse. The main components of the model are the presynaptic vesicle dynamics, which include passive and activity-dependent recycling, calcium-dependent exocytosis and the postsynaptic AMPA receptor kinetics. The behaviour of the model is compared to experimental data and reproduces the time course and amplitude of synaptic depression during repetitive stimulation at different frequencies. A comparison of different manipulations of the model shows that accurate fits require the inclusion of fast activity-dependent vesicle recycling and a limited number of vesicle docking sites at each active zone.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurocomputing - Volume 70, Issues 10–12, June 2007, Pages 1626–1629
نویسندگان
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