کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
408470 679031 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of Na+ channel inactivation kinetics on metabolic energy costs of action potentials
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر هوش مصنوعی
پیش نمایش صفحه اول مقاله
Effects of Na+ channel inactivation kinetics on metabolic energy costs of action potentials
چکیده انگلیسی

We investigate whether the inactivation properties of Na+Na+ channels in squid giant axons show evidence of having been optimized by evolution so as to reduce the energy expenditure associated with propagating action potentials. Using Hodgkin–Huxley-type models of the squid giant axon and varying the voltage dependence and overall scaling of the Na+Na+ inactivation rate, we find that faster inactivation rates correspond to less costly and more energy-efficient action potentials. However, and in contrast to the case when the ionic conductances and axon diameters are varied, the metabolic energy consumption does not have a minimum when restricted to an isovelocity curve in the phase space associated with these inactivation parameters. This failure-to-optimize encourages other hypotheses about the evolution and functionality of inactivation, such as its effects on information rates.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurocomputing - Volume 70, Issues 10–12, June 2007, Pages 1652–1656
نویسندگان
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