کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
408470 | 679031 | 2007 | 5 صفحه PDF | دانلود رایگان |

We investigate whether the inactivation properties of Na+Na+ channels in squid giant axons show evidence of having been optimized by evolution so as to reduce the energy expenditure associated with propagating action potentials. Using Hodgkin–Huxley-type models of the squid giant axon and varying the voltage dependence and overall scaling of the Na+Na+ inactivation rate, we find that faster inactivation rates correspond to less costly and more energy-efficient action potentials. However, and in contrast to the case when the ionic conductances and axon diameters are varied, the metabolic energy consumption does not have a minimum when restricted to an isovelocity curve in the phase space associated with these inactivation parameters. This failure-to-optimize encourages other hypotheses about the evolution and functionality of inactivation, such as its effects on information rates.
Journal: Neurocomputing - Volume 70, Issues 10–12, June 2007, Pages 1652–1656